Identification of an immune-related signature indicating the dedifferentiation of thyroid cells

Abstract Background Immune cells account for a large proportion of the tumour microenvironment in anaplastic thyroid carcinomas (ATCs). However, expression pattern immune-related genes (IRGs) ATCs is unclear. Our study aimed to identify an signature indicating dedifferentiation cells. Methods We compared differences differentiation score (TDS), infiltration immune and enriched pathways between papillary (PTCs) or normal tissues Gene Expression Omnibus database. Univariate multivariable Cox analyses were used screen prognosis-associated IRGs The Cancer Genome Atlas After constructing risk score, we investigated its predictive value survival by applying receiver operating characteristic Kaplan–Meier curves. further explored associations with important checkpoint molecules, infiltrating response immunotherapy. Results Compared PTCs tissues, exhibited lower TDS values higher enrichment activation inflammatory response. quantitative immunohistochemical staining validated that most ATC cell lines had MMP9 SDC2 than samples PTC. Higher scores indicates worse prognosis. Additionally, was positively correlated molecules PDL1, CTLA4, IDO1, HAVCR2 multiple Importantly, found tended have better immunotherapy those scores. Conclusion findings indicate may not only contribute determination prognosis but also help prediction